| Station Name | Network(s) | Channel | City / Town | Website | Notes |
| WLOX | ABC / CBS | 13 | Biloxi / Gulfport | wlox.com | Dual affiliation, local news leader |
| WXXV | FOX / NBC / CW | 25 | Biloxi / Gulfport | wxxv25.com | Multiple subchannels |
| WLOV | FOX / MyNetworkTV | 27 | Columbus / Tupelo | wlov.com | FOX for northeast MS |
| WABG | ABC / FOX | 6 | Greenville / Greenwood | wabg.com | Delta region, dual affiliation |
| WDAM | NBC / ABC | 7 | Hattiesburg / Laurel | wdam.com | WDAM-DT2 is ABC |
| WAPT | ABC | 16 | Jackson | wapt.com | Central MS ABC affiliate |
| WLBT | NBC | 3 | Jackson | wlbt.com | Oldest TV station in Jackson |
| WUFX | FOX | 35 | Jackson | gomiss.com/wufx | Branded as "Fox 35" |
| WTOK | ABC / CW / MyNetworkTV | 11 | Meridian | wtok.com | East MS news leader |
| WGBC | NBC / FOX | 30 | Meridian | wgbctv.com | WGBC-DT2 is FOX |
| WKDH | ABC (defunct) | 45 | Tupelo / Columbus | N/A | Ceased operations 2012 |
| WTVA | NBC / ABC | 9 | Tupelo / Columbus | wtva.com | WTVA-DT2 is ABC |